Genomics and Transcriptomics of the Blind Mole Rat (BMR), and Mechanisms Underlying its Hypoxia Tolerance
“Genomics and Transcriptomics of the Blind Mole Rat (BMR), and Mechanisms Underlying its Hypoxia Tolerance:” collaboration of University of Haifa with Beijing Genomics Institute (China) , Bar-Ilan University (Israel) and several universities in Europe and America.
A wide genomics study of BMR (NGS sequencing, assembly, and analysis of the BMR genome and transcriptome) that is focused on BMR’s adaptive response to underground stresses, and to hypoxia in particular. The NGS data analysis results reveal several specific adaptive genomic features of BMR, including high rates of RNA and DNA editing, reduced chromosome rearrangement, and an over-representation of SINE elements, etc. We have discovered specific regulations of expression of genes and repeats in BMR that lead to its tolerant response to hypercapnia and hypoxia, and, putatively, resistance to cancer.